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I3400 Sigma-Aldrich

Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: IP-10

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors,
Quality Level   100
biological source   human
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
mol wt   8.7 kDa
packaging   pkg of 10 μg
impurities   endotoxin, tested
UniProt accession no.   P01579
storage temp.   −20°C
Gene Information   human ... CXCL10(3627)

Description

Biochem/physiol Actions

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. It is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.

IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects. It is an ~8.7 kDa polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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