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I3525 Sigma-Aldrich

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: CTLA-8, IL-17

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized powder
potency   ≤2.0 ng/mL ED50
mol wt   31 kDa
packaging   pkg of 50 μg
impurities   endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... IL17A(3605)

Description

Biochem/physiol Actions

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Physical form

Lyophilized with no additives.

Analysis Note

• The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
• Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solution from which productI3525, Interleukin-17A human recombinant, was prepared?
Product I3525, Recombinant Human IL-17A, was lyophilized with no additives, which means it was lyophilized from water and may contain trace amounts of 0.1% TFA (pH 2.0) from being HPLC-purified.
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Peer-Reviewed Papers
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References

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