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I3650 Sigma-Aldrich

Interleukin-4 from rat

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Synonym: IL-4, rIL-4

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   rat
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
mol wt   predicted mol wt 13.5 kDa
packaging   pkg of 5 μg
impurities   endotoxin, tested
suitability   suitable for cell culture
UniProt accession no.   P20096
storage temp.   −20°C
Gene Information   rat ... Il4(287287)

Description

Biochem/physiol Actions

Interleukin-4 is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and bFGF-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Interleukin-4, a lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and bFGF-induced angiogenesis. Human and mouse IL-4 share 50% amino acid sequence identity, but their biological actions are species-specific.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The biological activity of recombinant rat IL-4 was measured by its ability to stimulate proliferation of rat splenocytes.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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