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I3653 Sigma-Aldrich

Anti-Interferon β antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IFN-β

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Description

General description

Type I interferons are proteins produced in response to inducers like viral infection and can be divided into α and β subtypes. IFN-β provokes high antiproliferation response in certain cells like embryonal carcinoma, melanoma and melanocytes. It also has high potency in treatment of multiple sclerosis and certain cancers. Anti-interferon β antibody can be used in western blot. Goat anti-interferon β antibody reacts specifically with human interferon-β and has shown no cross reactivity with recombinant human interferon-γ.

Specificity

The antibody will neutralize the biological activity of recombinant human IFN-β. It will not block the biological activity of recombinant human IFN-α or IFN-γ.

Immunogen

recombinant human IFN-β, expressed in Escherichia coli.

Application

Anti-interferon β antibody can be used in immunoblotting. It can also be used to neutralize the bioactivity of recombinant human interferon-β.

Physical form

Lyophilized from a solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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