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I3657 Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: IGFBP-2

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Description

General description

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Peer-Reviewed Papers
15

References

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