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I3909 Sigma-Aldrich

Ionomycin calcium salt

Ready Made Solution, from Streptomyces conglobatus, 1 mM in DMSO, 0.2 μm filtered

  • Empirical Formula (Hill Notation) C41H70CaO9

  • Molecular Weight 747.07

  •  EC Number 200-664-3

  •  MDL number MFCD00083634

  •  PubChem Substance ID 329815372

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Properties

Related Categories Antibiotic Ready Made Solutions, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents,
Quality Level   PREMIUM
biological source   Streptomyces conglobatus
InChI Key   WKRWUYKLUMMAKG-WYGBAUISSA-L
sterility   0.2 μm filtered
assay   ≥98% (HPLC)
shelf life   2 yr
concentration   1 mM in DMSO
color   colorless
mp   18.4 °C
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
shipped in   wet ice
storage temp.   −20°C

Description

Application

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

Biochem/physiol Actions

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.

Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It is used to study Ca2+ transport across biological membranes and induces apoptotic degeneration of embryonic cortical neurons.

Safety & Documentation

Safety Information

RIDADR 
NA 1993 / PGIII
WGK Germany 
1
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is Product No. I3909 (Ionomycin calcium salt solution) hygroscopic?
Yes, this product is hygroscopic.It is packaged under an inert gas.It is recommended to store I3909 under an inert gas and at -20°C protected from light.
What is the concentration of the Ionomycin calcium salt solution, Product No. I3909?
It is a 1mM solution or ~ 0.75mg/mL in DMSO.
HasIonomycin calcium salt solution, Product No. I3909, been tested for use in Cell Culture applications?
Sigma Aldrich has not tested this material for use in cell culture.However, several references for use of ionomycin in cell culture applications can be found in the product information sheet (under Documents, above).
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Peer-Reviewed Papers
15

References

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