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I4026 Sigma-Aldrich

Interleukin-17 from mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: CTLA-8, IL-17

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 16.5 kDa
packaging   pkg of 25 μg
impurities   endotoxin, tested
suitability   cell culture tested
UniProt accession no.   Q62386
storage temp.   −20°C
Gene Information   mouse ... Il17a(16171)

Description

Analysis Note

The biological activity of mouse IL-17 is measured by its ability to induce IL-6 production using NIH/3T3 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.

Biochem/physiol Actions

IL-17 (interleukin-17) participates in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways and CCAAT/enhancer-binding protein family of transcription factors, thereby regulating pro-inflammatory and antimicrobial genes. In rheumatoid arthritis, IL-17 is responsible for the inflammation as well as destruction of joints.

Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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