EMAIL THIS PAGE TO A FRIEND
I4125 Sigma-Aldrich

Inosine

≥99% (HPLC)

Synonym: (−)-Inosine, Hypoxanthine 9-β-D-ribofuranoside

  • CAS Number 58-63-9

  • Empirical Formula (Hill Notation) C10H12N4O5

  • Molecular Weight 268.23

  •  Beilstein Registry Number 624896

  •  EC Number 200-390-4

  •  MDL number MFCD00066770

  •  PubChem Substance ID 24896051

Purchase

Properties

Related Categories Cell Biology, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide,
InChI Key   UGQMRVRMYYASKQ-KQYNXXCUSA-N
assay   ≥99% (HPLC)
mp   222-226 °C (dec.) (lit.)

Description

Packaging

1, 5, 10, 25, 100 g in poly bottle

Application

Inosine has been used:
• as a medium supplement in nucleotide rescue experiments in pancreatic cancer cell lines.
• as a component in holidic (synthetic) medium and in larval two-choice preference assay.
• as a reference standard in mass spectroscopy.

Biochem/physiol Actions

Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.

General description

Inosine is a non-canonical nucleotide majorly present as monophosphate. It has ability to base pair with deoxythymidine, deoxyadenosine and deoxyguanosine. Incorporation of inosine in place of guanine modulates translational events. Inosine has antioxidant, anti-inflammatory and neuroprotective functionality. Inosine is prescribed as a therapeutic supplement for nerve injury, inflammation and oxidative stress. It modulates biological processes through adenosine receptors. Its enhances neurite outgrowth in depressive disorders via adenosine receptors. Inosine is also used for treating sepsis in infections.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

HPLC Analysis of Nucleosides on Ascentis® Express OH5 (HILIC Mode)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Express OH5 (HILIC Mode)
Keywords: Antivirals, Chromatography, High performance liquid chromatography, Metabolism

LC/MS Analysis of Nucleosides on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleosides on Ascentis® Express F5
Keywords: Antibiotics, Antivirals, Chromatography, Dimroth rearrangement, Fungicides, Genetic, Herbicides, High performance liquid chromatography, Industries, Insecticides, Liquid chromatography mass spectrometry, Mass spectrometry, Rearrangements

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

TLC Analysis of Nucleosides on HPTLC Silica gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Nucleosides on HPTLC Silica gel 60 RP-18 WF254s
Keywords: Chromatography, Thin layer chromatography

TLC Analysis of Nucleosides on HPTLC pre-coated plate RP-18 WF 254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Nucleosides on HPTLC pre-coated plate RP-18 WF 254s
Keywords: Agriculture, Thin layer chromatography

UHPLC Analysis of Nucleosides on Purospher® STAR RP-18 endcapped

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Nucleosides on Purospher® STAR RP-18 endcapped
Keywords: Antibiotics, Antivirals, Fungicides, Genetic, Herbicides, High performance liquid chromatography, Industries, Insecticides

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?