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I4276 Sigma-Aldrich

Interferon-αA human

≥95%, cell culture tested, buffered aqueous solution, recombinant, expressed in E. coli

Synonym: IFN-αA, Interferon-α2A

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥95%
form   buffered aqueous solution
mol wt   19 kDa
packaging   pkg of 20 μg
concentration   ≥0.2 mg/mL
impurities   endotoxin, tested
color   colorless
suitability   cell culture tested
UniProt accession no.   P01563
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IFNA2(3440)

Description

Application

Interferon-αA human has been used to:
• study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
• study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
• compare the effect of Monascus pigment derivatives on hepatitis C virus replication

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Physical form

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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06693 Timestrip Plus -20 °C

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