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I4402 Sigma-Aldrich

Insulin-like Growth Factor Binding Protein-4 human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: IGFBP-4

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in NSO cells
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   25 kDa by SDS-PAGE (non-reducing)
  32 kDa by SDS-PAGE (reducing)
purified by   affinity chromatography (IGF-I ligand)
packaging   pkg of 25 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
UniProt accession no.   P22692
storage temp.   −20°C
Gene Information   human ... IGFBP4(3487)

Description

Biochem/physiol Actions

IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time. IGFBP4 binds to IGF-1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to inhibit activity of recombinant human IGF-1 or recombinant human IGF-II on MCF-7 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Pipette Controller from Brand
Protocols & Articles

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Peer-Reviewed Papers
15

References

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