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  • I4902 - Anti-Interferon-α/β Receptor 1 antibody produced in goat

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I4902 Sigma-Aldrich

Anti-Interferon-α/β Receptor 1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IFN-α/β R1

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Description

General description

Interferon-α/β Receptor 1 is a dimeric, disulfide-linked protein that binds human interferons α and β. This receptor also interacts with Tyr kinase JAK1, and thereby regulates cellular signaling across the membranes . Anti-Interferon-α/β Receptor 1 is specific for recombinant human IFN-α/β R1 and does not react with recombinant human IFN-γ RI and IFN-γ RII.

Immunogen

recombinant human IFN-α/β R1 extracellular domain expressed in Sf21 insect cells.

Application

Anti-Interferon-α/β Receptor 1 antibody is suitable for use in flow cytometry (3-10 μg/test) and western blot (0.1-0.2 μg/mL). The antibody may also be used for immunoblotting (approx. 135kDa) and indirect immunofluorescence (using appropriate secondary antibodies).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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