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  • I5157 - Anti-IRAK-M antibody produced in rabbit

I5157 Sigma-Aldrich

Anti-IRAK-M antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Interleukin-1 Receptor-Associated Kinase



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Epigenetics and Nuclear Signaling, Antibodies for Gene Regulation,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 0.5-1 μg/mL
species reactivity   mouse, human, rat
mol wt   antigen mol wt ~68 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~0.5 mg/mL
UniProt accession no.   Q9Y616
Gene Information   human ... IRAK3(11213)
mouse ... Irak3(73914)
rat ... Irak3(314870)


General description

The gene IRAK3 (interleukin 1 receptor associated kinase 3), also referred to as IRAKM, encodes a member of the IRAK family. The members of this family are involved in several inflammatory processes. The encoded protein is selectively expressed in monocytes and macrophages. The gene is mapped to human chromosome 12q14.3.


synthetic peptide corresponding to amino acids 581-596 of human IRAK-M.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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Biochem/physiol Actions

The members of the IRAK (interleukin 1 receptor associated kinase) family, IRAK-1 and IRAK-4 form a complex with MyD88 (myeloid differentiation primary response 88) and TRAF-6 (TNF receptor associated factor 6), upon sensing of lipopolysaccharide by TLR-4 (Toll like receptor). This complex functions in internal signaling and activates MAPK (mitogen activated protein kinase) and NF (nuclear factor)-κB pathways. The protein encoded by IRAK-M, however, has a negative effect on the complex. It is an inhibitor of IRAK-1/IRAK-4 and negatively regulates Toll-like receptor signaling by inhibiting the dissociation of the complex formed by TLR-4 receptor activation. Mutations in this gene have been associated with the pathogenesis of early-onset persistent asthma.

Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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