EMAIL THIS PAGE TO A FRIEND
I5159 Sigma

Imiquimod

≥98% (HPLC), solid

Synonym: 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine

Purchase

Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   DOUYETYNHWVLEO-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   H2O: <2 mg/mL
  DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)

Description

Packaging

200 mg in glass bottle

Biochem/physiol Actions

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Discover your Target

Cell Culture Guide
Protocols & Articles

Articles

UHPLC Analysis of Nevirapine and Imiquimod on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Nevirapine and Imiquimod on Titan™ C18
Keywords: Chromatography, Mass spectrometry, Pharmaceutical

UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?