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I5403 Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Synonym: IGFBP-2



Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation,
biological source   human
recombinant   expressed in NSO cells
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
potency   0.04 μg/mL
mol wt   ~36 kDa by SDS-PAGE
  calculated mol wt ~31 kDa
packaging   pkg of 25 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
suitability   suitable for cell culture
UniProt accession no.   P18065
storage temp.   −20°C
Gene Information   human ... IGFBP2(3485)


General description

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


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