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I5902 Sigma-Aldrich

Monoclonal Anti-Interleukin-2 Soluble Receptor γ antibody produced in mouse

clone 38024.11, purified immunoglobulin, lyophilized powder

Synonym: Anti-IL-2 sRγ

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Properties

conjugate   unconjugated
clone   38024.11, monoclonal
biological source   mouse
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG1
antibody product type   primary antibodies
UniProt accession no.   P31785
Gene Information   human ... IL2RG(3561)

Description

General description

Interleukin-2 Receptor γ is a 64kD protein, that form complex with its β chain for IL-2 internalization and cell activation. It expresses in many cell types including neutrophils, thymocytes, CD4+ and CD8+ T cells, B cells, NK cells and monocytes. Mutation in IL2RG can leads to X-linked severe combined immunodeficiency (SCID) . Monoclonal anti-Interleukin-2 Soluble Receptor γ antibody can be used to block biological activity facilitated by IL-2. It can also be used for neutralizing the biological activity of IL-2 R γ. Mouse anti-Interleukin-2 Soluble Receptor γ antibody reacts specifically with human IL-2 soluble receptor γ. The product has shown no cross-reactivity with recombinant human IL-2 R α, IL-2 R β, IL-1 RI, IL-1 RII, IL-4 R, IL-6 R, IL-7 R and IL-10 R.

Immunogen

mouse cells transfected with human IL-2 soluble receptor γ.

Application

Monoclonal anti-Interleukin-2 Soluble Receptor γ antibody can be used in immunoblotting and ELISA for detecting IL-2 R γ.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Preparation Note

Purified using protein G.

Analysis Note

The antibody will neutralize human cell surface IL-2 Rγ mediated-bioactivity.

Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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