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I6034 Sigma-Aldrich

α-L-Iduronidase human

recombinant, expressed in mouse NSO cells



Related Categories 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates More...
recombinant   expressed in mouse NSO cells
activity   ≥7,500 units/μg protein
impurities   ≤1.0 EU/μg Endotoxin
shipped in   wet ice
storage temp.   −20°C


General description

α-L-Iduronidase is an enzyme encoded by IDUA gene; participate in lysosomal degradation of glycosaminoglycans. In human, mutation of gene encoding α-L-Iduronidase causes lysosomal storage diseases (mucopolysaccharidosis type I).


α-L-Iduronidase may be used for leukocyte assay in the study of a-L-Iduronidase deficiency in new born.

Biochem/physiol Actions

In lysosomal degradation process α-L-Iduronidase plays a crucial role. It hydrolyzes the non-reducing terminal α-L-iduronic acid residues in GAGs, including dermatan sulfate and heparan sulfate.

Catalyzes the hydrolysis of unsulfated α-L-iduronosidic linkages in dermatan sulfate

Physical properties

Expressed as C-terminal histine-tagged protein (residues 1-653) with a caluclated molecular mass of 71 kDa migrating at ~83 kDa under SDS-PAGE reducing conditions.

Unit Definition

One unit will produce 1 picomole of 4-methylumbelliferone from 4-methylumbelliferyl-α-L-iduronide per minute at pH 3.5 at 25 °C.

Physical form

Supplied as a solution in 40 mM sodium acetate , 400 mM NaCl and 20% (v/v) glycerol, pH 5.0

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles

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Application Index | Enzyme Index | Substrate Index | Inhibitor Index | Cofactor Index | Lectin Index
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