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I6138 Sigma-Aldrich

Idazoxan hydrochloride

Synonym: (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride, RX 781094

  • CAS Number 79944-56-2

  • Empirical Formula (Hill Notation) C11H12N2O2 · HCl

  • Molecular Weight 240.69

  •  MDL number MFCD00069293

  •  PubChem Substance ID 24278493

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I,
InChI Key   MYUBYOVCLMEAOH-UHFFFAOYSA-N
solubility   H2O: 50 mg/mL
Gene Information   human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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