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I6659 Sigma-Aldrich

Imperatorin

≥98% (HPLC), powder

Synonym: 8-Isopentenyloxypsoralene, 9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one, 9-[(3-Methyl-2-buten-1-yl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one, Ammidin, Marmelide, Marmelosin, NSC 402949

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I,
InChI Key   OLOOJGVNMBJLLR-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white to light brown
solubility   DMSO: ≥5 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.

Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that medi...
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell proliferation, Cellular processes, Clinical, Gene expression, Growth factors, Inflammation, Phosphorylations, Transcription, Transduction, transformation

Peer-Reviewed Papers
15

References

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