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I7018 Sigma-Aldrich

3-Isobutyl-1-methylxanthine

BioUltra, ≥99%

Synonym: 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX

  • CAS Number 28822-58-4

  • Empirical Formula (Hill Notation) C10H14N4O2

  • Molecular Weight 222.24

  •  Beilstein Registry Number 247859

  •  EC Number 249-259-3

  •  MDL number MFCD00005584

  •  PubChem Substance ID 24896107

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Properties

Related Categories Core Bioreagents, General Reagents, Life Science Reagents for RNAi, Nucleosides and Nucleotides, Research Essentials More...
InChI Key   APIXJSLKIYYUKG-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99%
impurities   <0.005% Phosphorus (P)
ign. residue   <0.1%
mp   200-201 °C (lit.)
solubility   DMSO: soluble 1 M (with gentle warning)
anion traces   sulfate (SO42-): <0.05%
cation traces   Al: <0.0005%
  Ca: <0.005%
  Cu: <0.0005%
  Fe: <0.005%
  K: <0.05%
  Mg: <0.005%
  NH4+: <0.05%
  Na: <0.005%
  Pb: <0.001%
  Zn: <0.0005%
storage temp.   −20°C
Gene Information   rat ... Adora1(29290), Adora2a(25369)

Description

Packaging

1 g in poly bottle

Application

3-Isobutyl-1-methylxanthine has been used:
• for adipogenic differentiation
• in tissue culture
• 3T3-L1 preadipocyte differentiation(

Biochem/physiol Actions

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
ZD8500000
Protocols & Articles
Peer-Reviewed Papers
15

References

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