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I7391 Sigma-Aldrich

Anti-I-309 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
UniProt accession no.   P22362
Gene Information   human ... CCL1(6346)

Description

General description

I-309 (CCL-1) is a member of CC chemokine family, secreted by monocytes/macrophages and T lymphocytes and acts as chemoattractant to dendritic cells, neutrophils, B and T lymphocytes, macrophages, basophils and neutrophils. I-309 exclusively binds to CCR8 receptor and activates the RAS/MAPK pathway. I-309 is also known to play important role in angiogenesis and tumoral processes and in development of thymocytes. In murine thymic lymphoma cells, anti-apoptotic and proliferative role of I-309 was observed. It is also implicated in recruitment of leukocytes and inhibition of CCR8-mediated HIV infection
Anti-I-309 antibody is specific for human I-309.

Immunogen

recombinant human I-309

Application

Anti-I-309 antibody may be for immunoblotting at a working antibody concentration of 1-2 μg/ml. Antibody concentration of 0.5-1 μg/ml may be used for ELISA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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