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  • I7654 - Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

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I7654 Sigma-Aldrich

Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IP3R-II

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: suitable
  immunoprecipitation (IP): suitable
species reactivity   rat
mol wt   antigen 240 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   P29995
Gene Information   rat ... Itpr2(81678)

Description

General description

The gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) encodes type 2 intracellular receptor that binds to Inositol 1,4,5 trisphosphate. The gene encodes a 2701 amino acid protein that contains six membrane-spanning regions near the C-termini. The cytoplasmic N-terminal domain is involved in ligand-binding. The gene is mapped to human chromosome 12p11.

Immunogen

synthetic petide with a sequence derived from the cytoplasmic, amino-terminus of rat IP3R-II.

Physical form

Solution in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The receptor encoded by the gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) is a Ca2+ release channel in the endoplasmic reticulum that is stimulated upon binding to its ligand inositol 1,4,5-triphosphate. It mediates intracellular calcium signaling. It facilitates the release of Ca2+ from endoplasmic reticulum and modulates intracellular Ca2+ concentration. Loss of ITPR2 gene function is found to be associated with anhidrosis and can inhibit sweat production in humans and mice.

Safety & Documentation

Safety Information

WGK Germany 
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Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
15

References

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