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I7892 Sigma-Aldrich

Anti-Interferon-γ Inducible Protein antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IP-10

  •  Beilstein/REAXYS Number 4294860

  •  MDL number MFCD01092385

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   IgG fraction of antiserum
Quality Level   200
antibody product type   primary antibodies
UniProt accession no.   P02778
Gene Information   human ... CXCL10(3627)

Description

General description

Interferon-γ Inducible Protein (IP-10), also known as CXCL-10, is a cytokine that belongs to the CXC chemokine family. It is secreted in response to interferon-γ by neutrophils, monocytes, basophils, epithelial cells and keratinocytes. IP-10 is involved in chemotaxis, apoptosis, angiostasis and inhibits cell growth. The effects of IP-10 are mediated by its receptor, CXCR3. The major signalling pathways that are activated by IP-10 are those of MAPK, PKA, JNK, NF-κB and PI3K/Akt. Alteration of IP-10 levels has been observed in various infectious diseases caused bacteria, fungi and viruses such as dengue, Ebola and hepatitis B
Anti-Interferon-γ Inducible Protein antibody detects human IP-10.

Immunogen

recombinant human IP-10.

Application

Anti-Interferon-γ Inducible Protein antibody may be used for immunoblotting at a working antibody concentration of 1-2 μg/ml. For ELISA, antibody concentration of 0.5-1.0 μg/ml is recommended.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Preparation Note

Purified using protein G.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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