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I7908 Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Synonym: IL-2, Interleukin-2, T-cell growth factor

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Properties

Related Categories Cell Biology, Cell Culture, Cytokines, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation, Cytokines, Growth Factors, Chemokines for Stem Cell Biology,
biological source   human
recombinant   expressed in Pichia pastoris
assay   ≥98% (SDS-PAGE and HPLC)
form   lyophilized powder
mol wt   predicted mol wt ~15 kDa
packaging   pkg of 10KU
impurities   endotoxin, tested
suitability   suitable for cell culture
UniProt accession no.   P60568
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... IL2(3558)

Description

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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