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  • I8153 - Anti-Interleukin-1 Receptor Accessory Protein antibody produced in rabbit

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I8153 Sigma-Aldrich

Anti-Interleukin-1 Receptor Accessory Protein antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IL-1RAcP

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Description

General description

Interleukin-1 is a proinflammatory cytokine produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that exert their cellular effects by signaling through IL-1 receptor type 1 (IL-1R1). IL-1 recruits Interleukin-1 Receptor Accessory Protein (IL-1RAcP) that stabilizes the ligand-receptor association. IL-1RAcP is expressed by astrocytes and neurons in the brain. IL-1RAcP does not regulate the responses of IL-1 directly but modulates the gene expression and inflammatory responses induced by IL-1. IL-1RAcP is critical in mediating the activation of IRAK and SAPK pathways by IL-1. Anti-Interleukin-1 Receptor Accessory Protein antibody recognizes human, mouse and rat IL-1RAcP (~66 kDa). There is no cross-reactivity to other members in the IL-1 and IL-18 receptor families.

Immunogen

synthetic peptide corresponding to amino acids 525-540 of human Interleukin-1 Receptor Accessory Protein (Il-1RAcP). This sequence is identical in mouse and rat.

Application

Anti-Interleukin-1 Receptor Accessory Protein antibody is suitable for immunoblotting at a working concentration of 0.5 μg/ml using HeLa cell extract.

Physical form

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

WGK Germany 
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Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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