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  • I8533 - Anti-Interleukin-21 antibody produced in goat

I8533 Sigma-Aldrich

Anti-Interleukin-21 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IL-21



Related Categories Alphabetical Index, Antibodies, IN-IP, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   capture ELISA: suitable
  neutralization: suitable
  western blot: 0.1-0.2 μg/mL
species reactivity   mouse
form   lyophilized powder
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   Q9ES17
Gene Information   mouse ... Il21(60505)


General description

Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. It is produced mainly by differentiated CD4+ T cells, natural killer T cells, Th17 and Th1 cells and T follicular helper cells. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. It also activates the MAPK signalling. IL-21 is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation. Deregulation of IL-21 production results in autoimmune disorders including systemic lupus erythematosus, multiple sclerosis and gastrointestinal inflammatory diseases
Anti-Interleukin-21 detects mouse interleukin 21. The antibody shows approximately 5% cross-reactivity with recombinant human IL-21 and less than 1% cross-reactivity with recombinant mouse IL-2.


purified, E. coli-derived, recombinant mouse IL-21.


Anti-Interleukin-21 antibody may be used for ELISA at a working concentration of 0.4 μg/ml. For immunoblotting, the recommended concentration is 0.1-0.2 μg/ml. The antibody is suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 7.4, containing 5% trehalose.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles


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