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I8657 Sigma-Aldrich

Interferon α from rat

≥95%, recombinant, expressed in bacteria, lyophilized powder, cell culture tested

Synonym: IFN-α

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   rat
recombinant   expressed in bacteria
assay   ≥95%
form   lyophilized powder
mol wt   mol wt ~19 kDa
packaging   pkg of 1 vial
concentration   300,000-700,000,000 units/mL
suitability   cell culture tested
UniProt accession no.   P05011
shipped in   dry ice
storage temp.   −70°C
Gene Information   rat ... Ifna_mapped(24480)

Description

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV) in the presence of 2mM glutathione. The cytopathic effect of 50% is produced with ~1 unit/mL interferon. Since there is no international rat interferon α standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Physical form

Lyophilized from a solution containing citric acid buffered saline (CBS pH 5.0) and 125 mM trehalose

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Peer-Reviewed Papers
15

References

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