• USA Home
  • I8779 - Insulin-like Growth Factor-I from mouse

EMAIL THIS PAGE TO A FRIEND
I8779 Sigma-Aldrich

Insulin-like Growth Factor-I from mouse

IGF-I, recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: IGF-I

Purchase

Description

Analysis Note

The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.

Biochem/physiol Actions

Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.

Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.

IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.

Packaging

50 μg in glass insert

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

Articles

Huntington's Disease

Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction,...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 9–14
Keywords: Apoptosis, Huntington Disease, Transcription

Insulin-like Growth Factors (IGF)

Insulin-like growth factors (IGF-I and IGF-II) are mitogenic and anabolic peptides structurally homologous to insulin. IGF-I and -II are single polypeptide chains of approximately 7.5 kDa comprised o...
Jennifer Fries
BioFiles 2009, 4.5, 12.
Keywords: Adhesion, Apoptosis, Biofiles, Cancer, Growth factors, Hormones, Infrared spectroscopy, Ligands, Transduction, transformation

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

I2656 Insulin-like Growth Factor-I (E3R) human, >95% (HPLC), recombinant, expressed in E. coli, lyophilized powder
I2157 Anti-Insulin-Like Growth Factor-I antibody produced in goat, affinity isolated antibody, lyophilized powder
I9409 Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster, clone 126002, purified immunoglobulin, lyophilized powder
I9909 Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in mouse, clone 56408, purified immunoglobulin, lyophilized powder
I1146 R3 IGF-1 human, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C
I9278 Insulin solution human, Chemically defined, recombinant, expressed in Saccharomyces cerevisiae, sterile-filtered, BioXtra, suitable for cell culture
I3769 Insulin-like Growth Factor-I human, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
I8773 Anti-Insulin-Like Growth Factor-I antibody produced in goat, affinity isolated antibody

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?