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I8782 Sigma-Aldrich

Interferon αA from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, cell culture tested

Synonym: IFN-αA

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥95%
form   buffered aqueous solution
mol wt   20 kDa
color   colorless
suitability   cell culture tested
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... Ifna3(110218)

Description

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Packaging

Minimum 1x105 units/vial.

Physical form

Solution in phosphate buffered saline containing 0.1% bovine serum albumin.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon α.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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