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I8907 Sigma-Aldrich

Interferon β from rat

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Synonym: IFN-β

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   rat
recombinant   expressed in CHO cells
assay   ≥95%
form   lyophilized powder
mol wt   mol wt ~20 kDa
packaging   pkg of 1 vial
concentration   ≥100000 units/mL
suitability   suitable for cell culture
UniProt accession no.   P70499
shipped in   dry ice
storage temp.   −70°C
Gene Information   rat ... Ifnb1(24481)

Description

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.

Physical form

Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

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Peer-Reviewed Papers
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References

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