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I9032 Sigma-Aldrich

Interferon β from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Synonym: IFN β

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
Quality Level   200
biological source   mouse
recombinant   expressed in E. coli
assay   ≥95%
form   buffered aqueous solution
mol wt   ~20 kDa
packaging   pkg of 1 vial
concentration   2560000 units/mL
application(s)   cell culture | mammalian: suitable
UniProt accession no.   P01575
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... Ifnb1(15977)

Description

General description

IFN β (interferon β) is from the type 1 interferon family of cytokines.

Biochem/physiol Actions

In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response. It is also important for anti-inflammatory effects.

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Physical form

Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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