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I9032 Sigma-Aldrich

Interferon β from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, cell culture tested

Synonym: IFN β

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥95%
form   buffered aqueous solution
mol wt   ~20 kDa
packaging   pkg of 1 vial
concentration   2560000 units/mL
suitability   cell culture tested
UniProt accession no.   P01575
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... Ifnb1(15977)

Description

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response. It is also important for anti-inflammatory effects.

Physical form

Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.

General description

IFN β (interferon β) is from the type 1 interferon family of cytokines.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
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Peer-Reviewed Papers
15

References

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