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I9657 Sigma-Aldrich

Ionomycin from Streptomyces conglobatus

≥98% (HPLC)

  • CAS Number 56092-81-0

  • Empirical Formula (Hill Notation) C41H72O9

  • Molecular Weight 709.00

  •  Beilstein Registry Number 3642126

  •  MDL number MFCD06798385

  •  PubChem Substance ID 24896159

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
Quality Level   PREMIUM
biological source   Streptomyces conglobatus
InChI Key   PGHMRUGBZOYCAA-ADZNBVRBSA-N
assay   ≥98% (HPLC)
solubility   acetonitrile: 10 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   −20°C

Description

Packaging

1, 5 mg in glass bottle

Application

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

Biochem/physiol Actions

Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NO0600000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers
15

References

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