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  • I9660 - Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

I9660 Sigma

Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

clone PM6/248, purified from hybridoma cell culture

Synonym: Anti-CD41, Anti-CD41B, Anti-GP2B, Anti-GTA, Anti-ITGA2B integrin, alpha 2b



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
species reactivity   baboon, human
application(s)   flow cytometry: 1-2 μg/mL using human platelets
  immunoprecipitation (IP): suitable
clone   PM6/248, monoclonal
concentration   ~1.0 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ITGA2B(3674)
biological source   mouse
conjugate   unconjugated



human platelet membranes

General description

The gene ITGA2B (integrin subunit α 2b) encodes one of the 18 α subunits of integrins, which are transmembrane α/β heterodimers. The heterodimers, in mammals, are made up of a combination of one of 18 possible α subunits together with one of eight β subunits. The α and β subunits are type-I membrane proteins that contain a single transmembrane region linking a large extracellular domain and short noncatalytic cytoplasmic tail.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The heterodimer αIIbβ3 functions primarily in platelet aggregation, a crucial process in hemostasis and thrombosis. Integrin αIIbβ3, also referred to as glycoprotein IIbIIIa is a major adhesion receptor on platelets that is capable of binding to fibrinogen upon platelet stimulation. Defects in this gene have been associated with Glanzmann thrombasthenia, an autosomal recessive bleeding disorder.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers


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