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I9784 Sigma-Aldrich

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in mouse

clone 75015, purified immunoglobulin, lyophilized powder

Synonym: Anti-IGF2, Anti-INSIGF

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Insulin-like Growth Factors (IGF),
conjugate   unconjugated
clone   75015, monoclonal
biological source   mouse
application(s)   neutralization: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG1
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P01344
Gene Information   human ... IGF2(3481)

Description

Immunogen

purified, E. coli-derived recombinant human insulin-like growth factor-II.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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I7276 Anti-Insulin-Like Growth Factor-II antibody produced in goat, affinity isolated antibody, lyophilized powder
I8904 Insulin-like Growth Factor-II from mouse, IGF-II, recombinant, expressed in E. coli, lyophilized powder
I2282 Anti-Insulin-Like Growth Factor-II antibody produced in goat, affinity isolated antibody, lyophilized powder
I9534 Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat, clone 122404, purified immunoglobulin, lyophilized powder
I9659 Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in mouse, clone 75014, purified immunoglobulin, lyophilized powder
I2526 Insulin-like Growth Factor-II human, IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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