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I9785 Sigma-Aldrich

Imidazolo-oxindole PKR inhibitor C16

≥98% (HPLC)

Synonym: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression,
InChI Key   VFBGXTUGODTSPK-BAQGIRSFSA-N
assay   ≥98% (HPLC)
color   yellow to orange-brown
solubility   DMSO: 12 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Application

Imidazolo-oxindole PKR inhibitor C16 has been used:
• to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
• to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
• to augment eukaryotic translation initiation factor 2 (eIF2) activity

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

C16 exhibits a neuroprotective role in adult brain injuries.

Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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