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I9905 Sigma-Aldrich

Interleukin-2/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, solution

Synonym: IL-2:Fc (non-lytic)

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Description

Biochem/physiol Actions

IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).

Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain.

Other Notes

Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Analysis Note

The biological activity is measured in a cell proliferation assay using CTLL2 cells.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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