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J3705 Sigma-Aldrich

JB1 trifluoroacetate salt

≥98% (HPLC)

Synonym: H-Cys-Tyr-Ala-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Cys-OH trifluoroacetate salt, JB-1 trifluoroacetate salt, L-Cysteinyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-Cysteine, cyclic (1-12)-disulfide trifluoroacetate salt

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, J
InChI Key   MPUVBZQBFGGAAS-XHGDPFBQSA-N
assay   ≥98% (HPLC)
form   film
storage condition   desiccated
shipped in   wet ice
storage temp.   −20°C

Description

Packaging

1 mg in glass bottle

Biochem/physiol Actions

JB1 is an IGF-I peptide analog; IGF-1 receptor antagonist. IGF-1, once known as somatomedin C, is involved in a multitude of activites including promoting growth and development, particularly neural development, and involved in the growth and proliferation in a variety of human cancers. JB1 is a 12-amino acid cyclic peptide, an IGF-1 analog, used by researchers in a variety of fields to inhibit IGF activity by inhibiting binding of IGF-1 to its receptor.

Features and Benefits

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

InsR

The insulin receptor belongs to a subfamily of receptor tyrosine kinases that also includes the IGF-1 receptor and an orphan receptor called the insulin receptor-related receptor (IRR). It is a tetra...
Keywords: Atomic absorption spectroscopy, Cancer, Diabetes, Gastrointestinal, Gene expression, Genetic, Glycosylations, Growth factors, Infrared spectroscopy, Ligands, Obesity, Phosphorylations

Peer-Reviewed Papers
15

References

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