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J4080 Sigma-Aldrich

JTE-013

≥98% (HPLC)

Synonym: 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide

  • CAS Number 383150-41-2

  • Empirical Formula (Hill Notation) C17H19N7OCl2

  • Molecular Weight 408.29

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, J,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: ≥20 mg/mL
storage temp.   2-8°C

Description

Application

JTE-013 has been used in in vitro blood−brain barrier (BBB) and blood−tumor barrier (BTB) assays.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist. JTE-013 is highly selective for S1P2 (EDG-5). It inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 mM, JTE-013 displays 4.2% inhibition of S1P3 and does not antagonise S1P1.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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