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J4137 Sigma-Aldrich

JS-K

≥97%

Synonym: O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate

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Properties

Related Categories Application Index, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   DNJRNBYZLPKSHV-RGEXLXHISA-N
assay   ≥97%
storage condition   desiccated
solubility   DMSO: soluble 9.3 mg/mL
  H2O: insoluble
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

Nitric oxide donor; antiproliferative.

JS-K belongs to the class of diazeniumdiolate prodrug. It generates nitric oxide when metabolized by glutathione S-transferases (GST), which ensures optimal activity of JS-K. It has tumor growth inhibition action in human prostate cancer and leukemia.

Packaging

25 mg in poly bottle

5 mg in glass bottle

Legal Information

Covered by US Patent No 6,610,660

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TL1364200

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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