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J4455 Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Synonym: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

  • CAS Number 749886-87-1

  • Empirical Formula (Hill Notation) C16H20N2

  • Molecular Weight 240.34

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   off-white to gray-pink
solubility   DMSO: >10 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Other Notes

Light and air sensitive.

Packaging

5, 25 mg in glass bottle

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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