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J4455 Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Synonym: 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

  • CAS Number 749886-87-1

  • Empirical Formula (Hill Notation) C16H20N2

  • Molecular Weight 240.34

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   off-white to gray-pink
solubility   DMSO: >10 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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