J4649 Sigma-Aldrich


≥98% (HPLC), solid

Synonym: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine, RWJ 540973

  • CAS Number 627518-40-5

  • Empirical Formula (Hill Notation) C18H16FN3O2

  • Molecular Weight 325.34

  •  PubChem Substance ID 329815736



Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: >10 mg/mL
  H2O: <2 mg/mL
originator   Johnson & Johnson
storage temp.   −20°C



1, 5 mg in glass bottle

Biochem/physiol Actions

JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at

This compound is featured on the PAF Receptor and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles


Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

PAF Receptors

Following the identification of Platelet-Activating Factor (PAF) in 1972, and structural confirmation in 1979, there was intense interest in the biology of this phospholipid. These early studies demo...
Keywords: Angiogenesis, Atomic absorption spectroscopy, Clinical, Diseases, Gene expression, Inflammation, Ligands, Metabolic Pathways, Oxidations, Reproduction, Transduction


Platelet-derived growth factor (PDGF) is a family of disulfide-bonded dimeric molecules of A-, B-, C- and D-polypeptide chains (PDGF-AA, -AB, -BB, -CC and -DD). PDGF isoforms stimulate proliferation,...
Keywords: Atomic absorption spectroscopy, Cell proliferation, Central Nervous System, Diseases, Gastrointestinal, Growth factors, Ligands, Phosphorylations, Solid state metathesis, Transcription, transformation

Peer-Reviewed Papers


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