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K0253 Sigma-Aldrich

Keratin from human epidermis

aqueous solution

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
Quality Level   200
biological source   human epidermis
assay   ≥90% (SDS-PAGE)
form   urea solution
application(s)   ELISA: suitable
storage temp.   2-8°C
Gene Information   human ... KRT1(3848)

Description

General description

In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13.

Keratins are characteristic intermediate filament proteins of the epithelia. There are 54 functional keratin genes in humans. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.It is the primary component of hair, skin and nails

Application

Keratin from human epidermis has been used as a standard in enzyme linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis.

Physical form

Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4

Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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