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K1136 Sigma-Aldrich

Ketorolac tris salt

≥99%, crystalline

Synonym: (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt, Toradol

  • CAS Number 74103-07-4

  • Empirical Formula (Hill Notation) C15H13NO3 · C4H11NO3

  • Molecular Weight 376.40

  •  MDL number MFCD00887595

  •  PubChem Substance ID 24278503

  •  NACRES NA.77

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Properties

Related Categories A to C, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents, Cell Biology,
Quality Level   100
biological source   synthetic (organic)
assay   ≥99%
form   crystalline
solubility   H2O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
storage temp.   room temp
SMILES string   NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI   1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI key   BWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Information   human ... PTGS1(5742), PTGS2(5743)

Description

Application

Ketorolac has been used:
• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caution

Stable at least 2 years if stored at room temperature.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
UY7759900
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

References

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