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K1513 Sigma-Aldrich

Kendomycin from Streptomyces violaceoruber

solid

Synonym: (−)-TAN 2162

  • CAS Number 183202-73-5

  • Empirical Formula (Hill Notation) C29H42O6

  • Molecular Weight 486.64

  •  MDL number MFCD00076711

  •  PubChem Substance ID 24896208

  •  NACRES NA.77

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Properties

Related Categories A - K, Antagonists, Antibacterial, Antibiotics, Antibiotics A to Z,
Quality Level   200
form   solid
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  neoplastics
storage temp.   −20°C
SMILES string   CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(C)C(O)=O
InChI   1S/C32H61N13O9/c1-15(2)13-19(33)25(48)42-21(10-8-12-39-32(36)37)27(50)43-20(9-7-11-38-31(34)35)26(49)40-17(5)24(47)44-22(14-46)28(51)45-23(16(3)4)29(52)41-18(6)30(53)54/h15-23,46H,7-14,33H2,1-6H3,(H,40,49)(H,41,52)(H,42,48)(H,43,50)(H,44,47)(H,45,51)(H,53,54)(H4,34,35,38)(H4,36,37,39)
InChI key   PPBZOEOSJVJLRX-UHFFFAOYSA-N

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Potent endothelin receptor antagonist. Antiosteoporotic compound. Shows also remarkable antibacterial and cytotoxic activity. A putative cellular target for cytotoxicity has been identified: inhibition or altered regulation of the proteasome.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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