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K1757 Sigma-Aldrich

Keratinocyte Growth Factor human

KGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym: FGF-7, KGF, hFGF-7, hKGF

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE and HPLC)
form   powder
potency   1.0-10 ng/mL ED50/EC50
quality   endotoxin tested
mol wt   mol wt 18.9 kDa
packaging   pkg of 10 and 50 μg
impurities   1 EU/μg
suitability   suitable for cell culture
UniProt accession no.   P21781
storage temp.   −20°C
Gene Information   human ... FGF7(2252)

Description

Analysis Note

The proliferative activity is tested in culture using the murine hematopoietic cell line BaF3.

Biochem/physiol Actions

Keratinocyte growth factor (KGF, 18.9 kDa, 163 amino acids) includes a secretory signal sequence and shares 39% identity with FGF-Basic. It is expressed in a number of stromal fibroblast cell lines but absent from normal glial cells and epithelial cell lines. KGF stimulates proliferation and differentiation of keratinocytes and other cells in the epithelium and induces chemotaxis of microvascular endothelial cells and neovascularization of rat cornea.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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06693 Timestrip Plus -20 °C

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