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K2010 Sigma-Aldrich

α-Ketoglutaric acid sodium salt

BioUltra

Synonym: 2-Oxoglutaric acid monosodium salt, 2-Oxopentanedioic acid monosodium salt, Sodium 2-oxoglutarate monobasic

  • CAS Number 22202-68-2

  • Linear Formula HOOCCH2CH2COCOONa

  • Molecular Weight 168.08

  •  Beilstein Registry Number 4597521

  •  EC Number 244-836-6

  •  MDL number MFCD00064196

  •  PubChem Substance ID 24896216

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Properties

Related Categories Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, Enzyme Substrates,
InChI Key   MOTOGHHLNTXPTI-UHFFFAOYSA-M
product line   BioUltra
impurities   ≤0.0005% Phosphorus (P)
  ≤0.1% Insoluble matter
solubility   H2O: 0.5 M, clear, colorless
anion traces   chloride (Cl-): ≤0.05%
  sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.001%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  NH4+: ≤0.05%
  Pb: ≤0.001%
  Zn: ≤0.0005%
storage temp.   2-8°C

Description

Packaging

5, 25, 100 g in poly bottle

Application

α-Ketoglutaric acid sodium salt has been used in the human kynurenine amino transferase II (KAT II) inhibition spectra assay.

Biochem/physiol Actions

α-Ketoglutaric acid is the precursor for L-glutamic acid.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

Chiral 2-hydroxyglutarates (2-OHG) are important molecular signatures of their specific biochemical pathways and inborn errors of metabolism, for both healthy and diseased biological cells. For examp...
Roland Wöhlgemuth, Rudolf Köhling, Hugh Cramer
Reporter Volume 31.3
Keywords: Asymmetric synthesis, Cancer, Citric Acid Cycle, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites, Phase transitions, Reductions, Separation

Citric Acid Cycle, TCA or Krebs Cycle

Acetyl-CoA enters a cycle whose discovery by Hans Krebs 70 years ago marked a milestone in biochemistry. The citric acid cycle is also termed the tricarboxylic acid cycle, TCA cycle or Krebs cycle (s...
BioFiles 2007, 2.6, 16.
Keywords: Addition reactions, Biochemistry, Catalysis, Citric Acid Cycle, Decarboxylations, Dehydration reaction, Hydration reaction, Metabolites, Oxidations, Phosphorylations

Fatty Acid Synthesis and Metabolism in Cancer Cells

Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Biofiles, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Biofiles, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Support, Transcription

LCMS Separation and Identification of 2-Hydroxyglutarates

Sigma-Aldrich has recently developed an application for the separation and identification of S-2-hydroxyglutaric acids and R-2-hydroxyglutaric acids by chiral LC-MS, using a CHIROBIOTIC® R Column (co...
Keywords: AGE, Cancer, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Reductions, Separation, Tools

Peer-Reviewed Papers
15

References

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