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K3125 Sigma-Aldrich

Kojic acid

Synonym: 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone

  • CAS Number 501-30-4

  • Empirical Formula (Hill Notation) C6H6O4

  • Molecular Weight 142.11

  •  Beilstein/REAXYS Number 120895

  •  EC Number 207-922-4

  •  MDL number MFCD00006580

  •  PubChem Substance ID 24896226

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
Quality Level   200
assay   ≥98.5% (HPLC)
form   powder
mp   152-155 °C (lit.)
SMILES string   OCC1=CC(=O)C(O)=CO1
InChI   1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChI key   BEJNERDRQOWKJM-UHFFFAOYSA-N

Description

Application

Kojic acid has been used:
• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
• as a reference inhibitor standard for screening tyrosinase inhibition
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells

Packaging

5, 10, 25 g in poly bottle

Biochem/physiol Actions

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.

Tyrosinase inhibitor.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
UQ0875000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

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Peer-Reviewed Papers
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