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K4143 Sigma

PKCη, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: MG C26269, MG C5363, PKCL, PRK CL, PRKCH, nPKC-eta



Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   73-99 nmol/min·mg
mol wt   mol wt ~73 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PRKCH(5583)


Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

PKCη (protein kinase C η) mainly participates in terminal differentiation of keratinocytes. It is responsible for arresting the cell cycle at G1 phase. It is also involved in phosphorylation of p21 and suppression of cdk2 (cyclin-dependent kinase 2) kinase activity by associating with cyclin E/cdk2/p21 complex, thereby regulating cell cycle. PKCη is upregulated in breast cancer and is associated with cell growth.

General description

PKCη (protein kinase C η) belongs to the protein kiinase C family. It is mainly expressed in the squamous cell epithelia.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 

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