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L1290 Sigma-Aldrich

Lactoferricin B, fragment 4-14 trifluoroacetate salt

≥95% (HPLC)

Synonym: bLFC (26-36), bovine lactoferricin

  • Empirical Formula (Hill Notation) C70H113N25O13S

  • Molecular Weight 1544.87

  •  MDL number MFCD04040902

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal,
assay   ≥95% (HPLC)
solubility   H2O: soluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly

Biochem/physiol Actions

Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.

Lactoferricin B also suppresses liver and lung metastasis in murine melanomas and lymphomas. In addition, it causes cell death in human leukemic and carcinoma cell lines. It is effective against Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Proteus vulgaris, Yersinia enterocolitica, Pseudomonas aeruginosa, Campylobacter jejuni, Staphylococcus aureus, Streptococcus mutans, Corynebacterium diphtheriae, Listeria monocytogenes and Clostridium perfringens.

Application

Lactoferricin B, fragment 4-14 trifluoroacetate salt has been used to study effect of lactoferricin on cell proliferation of human colon cancer cells. It has been used in study of ultraviolet light-mediated DNA damage in human colon cancer cells.

General description

Chemical structure: peptide

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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