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L2913 Sigma-Aldrich

Leptomycin B solution from Streptomyces sp.

≥95% (HPLC), Supplied in methanol: water (7:3)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Bioactive Small Molecule Alphabetical Index,
Quality Level   PREMIUM
InChI Key   YACHGFWEQXFSBS-XYERBDPFSA-N
assay   ≥95% (HPLC)
storage condition   protect from light
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
shipped in   dry ice
storage temp.   −20°C

Description

General description

Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.

Biochem/physiol Actions

Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.

Other Notes

The volume in each sku is 0.1 mL with 10-20% overpack.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
64.4 °F
Flash Point(C) 
18 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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