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L6038 Sigma-Aldrich

LH-RH Fragment 1-4

>98% (HPLC)

  • Empirical Formula (Hill Notation) C25H29N7O7

  • Molecular Weight 539.54

  •  MDL number MFCD03452958

  •  PubChem Substance ID 329817635

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
assay   >98% (HPLC)
storage temp.   −20°C
SMILES string   N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CO)C(O)=O
InChI   1S/C25H31N7O8/c26-16(5-6-21(34)35)22(36)30-19(8-14-10-27-12-29-14)24(38)31-18(23(37)32-20(11-33)25(39)40)7-13-9-28-17-4-2-1-3-15(13)17/h1-4,9-10,12,16,18-20,28,33H,5-8,11,26H2,(H,27,29)(H,30,36)(H,31,38)(H,32,37)(H,34,35)(H,39,40)/t16-,18-,19-,20-/m0/s1
InChI key   FMJXVANOHHICFP-LEAZDLGRSA-N
Gene Information   human ... GNRH1(2796), GNRHR(2798)
mouse ... GNRH1(14714), GNRHR(14715)
rat ... GNRH1(25194), GNRHR(81668)

Description

Amino Acid Sequence

Glp-His-Trp-Ser

Biochem/physiol Actions

Glp-His-Trp-Ser is fragment 1-4 of GnRH (gonadotropin-releasing hormone). GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred to as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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